Synthesis, formulation and quality control of Mebrofenin (BRIDA) as a 99mTc-KIT for cholescintigraphy [Persian]

Document Type: Original Article


Department of Radioisotope, Nuclear Research Center, AOEI, Tehran, Iran


This article will review the essential chemical structure of IDA derivatives and their biokinetic characteristics as the hepatobiliary agents. The article also presents the procedures of Synthesis, formulation and Quality control of mebrofenin (BRIDA) as a 99mTc-Radiopharmaceuticai kit which is produced in Radioisotope Division of N.R.C. 99mTc-BRiDA has extremely low renal excretion and hence greater hepatic specificity. In addition, the BRIDA is much more resistant to Markedly elevated levels of bilirubin rather than the other IDA'S analogs.

Main Subjects