Echocardiographic left ventricular functional changes in acute hypothyroidism vs. subclinical hyperthyroidism in patients with differentiated thyroid carcinoma

Document Type: Original Article

Authors

1 Nuclear Medicine Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Cardiovascular Research Center, Department of Cardiovascular Diseases, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Abstract

Introduction:  In order to assess echocardiographic left ventricular functional indices in patients with differentiated thyroid carcinoma (DTC), after L-T4 withdrawal (short-term overt hypothyroidism) and during TSH suppressive therapy, we have evaluated cardiac hemodynamics in a single cohort study. Methods: 24 patients with DTC were studied in two phases: 1: at least 4 weeks after L-T4 withdrawal, 2: at least 8 weeks after beginning TSH suppressive therapy. All patients underwent conventional, Doppler and tissue Doppler echocardiography.  Results: Although early diastolic mitral inflow velocity (E wave) (p=0.033), and early diastolic velocity of mitral annulus [E(m)] (p Conclusion: Short-term overt hypothyroidism or L-T4 suppressive therapy in patients with DTC may have undesirable cardiovascular effects. So in patients with known history of cardiovascular abnormalities, the caring physician should be aware of the cardiovascular complications during hypothyroidism or suppressive therapy.

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