Synthesis, formulation and quality control of 99mTc-MAG3, as a renal tubular 99mTc-radiopharmaceutical kit [Persian]

Document Type: Original Article

Authors

Department of Radioisotope, Nuclear Research Center, AOEI, Tehran, Iran

Abstract

Radionuclidic techniques may provide assessment of glomerular filtration rate (GFR) effective renal plasma flow (ERPF) or individual renal function. Several agents were available for determination of these parameters such as ¹³¹I-OIH (O-iodohippurate) and different derivatives of DADS (Diamidodisulfur). OIH has the disadvantage of imparting a relatively high absorbed radiation dose to the patient at low diagnostic doses. First experiment with 99mTc-MAG3 in mice and rats indicated an essentially complete renal elimination with faster excretion rates and higher excretion efficiencies than for OIH. The superior physical properties of 99mTc for gamma camera imaging replaced 99mTc-MAG3 as a renal tubular agent. Here in, we report synthesis, formulation and quality control of 99mTc-MAG3 as a renal tubular 99mTc-radiopharmaceutical kit. The Bz-MAG3 and its precursors were characterized by FTIR spectroscopy.

Main Subjects