Iranian Journal of Nuclear Medicine

Iranian Journal of Nuclear Medicine

Innovative quantitative analysis of left ventricular axis from cardiac SPECT images: XCAT phantom study and clinical validation

Document Type : Original Article

Authors
Fatemeh Salahshourinejad 1
Ahmad Keshavarz 1
Esmail Jafari 2, 3
Majid Assadi 2, 3
1 Electrical Engineerimg Department, Faculty of Intelligent Systems Engineering and Data Science, Persian Gulf University, Bushehr, Iran
2 The Persian Gulf Nuclear Medicine Research Center, Bushehr University of Medical Sciences, Bushehr, Iran
3 Department of Nuclear Medicine, Molecular Imaging and Theranostics, Bushehr Medical University Hospital, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
10.22034/irjnm.2024.129414.1578
Abstract
Introduction: In this study, we aimed to evaluate the possibility of assessing cardiac abnormality using the left ventricular anatomical axis (LVAA) obtained from short-axis views of myocardial perfusion imaging (MPI).
Methods: To obtain LVAA, an ellipse was drawn around the outer wall of SPECT images from XCAT phantoms and patients. The best line was then drawn from the center of all the ellipses in the short-axis views called LVAA. Then, we defined two angles based on LVAA including Ɵ which is the angle created by LVAA with the x-axis, and Φ which is the angle created by LVAA with the z-axis.
Results: In this study, 94 cases were enrolled including 48 males (51%) and 46 females (49%) with a mean age of 65.65±10.04. According to the results, there was a significant difference between the two obtained angles and the result of the scan (p<0.05). The ideal cut-off of Ɵ for an abnormal scan was 91.79 (AUC, 0.93; p=0.001) with the sensitivity of 98% and specificity of 80%.
Conclusion: It can be concluded that LVAA as a quantitative factor is significantly different between normal and abnormal MPS and can be used for the evaluation of MPI.
Keywords
Myocardial perfusion imaging
SPECT
Cardiovascular imaging
Left ventricular axis
[99mTc]Tc-MIBI
Subjects
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