Iranian Journal of Nuclear Medicine

Iranian Journal of Nuclear Medicine

Enhancing restaging of a colorectal cancer patient: The advantage of [99mTc]Tc-FAPI-46 over conventional CT in detecting metastases

Document Type : Case Report

Authors
Mohammad Ahmadi 1
Mohammad Hadi Samadi 1
Pegah Sahafi 1
Ehsan Soltani 2
Atena Aghaee 1
1 Nuclear Medicine Research Center, Mashhad University of Medical Science, Mashhad, Iran
2 Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
10.22034/irjnm.2025.130027.1679
Abstract
 We report the case of a 73-year-old male with a history of colon adenocarcinoma, diagnosed 18 months prior. The patient underwent total colectomy and chemoradiotherapy 15 months previously. Due to recurrent abdominal pain, a metastatic workup was conducted utilizing both contrast-enhanced CT scan and [99mTc]Tc-FAPI-46 SPECT/CT. The latter imaging identified three metastatic lesions, while the contrast-enhanced CT scan detected only one peritoneal deposit. The two remaining metastases were small and hidden between the bowel loops and were not obvious on the conventional CT images. This case demonstrates that [99mTc]Tc-FAPI-46 SPECT/CT offers enhanced sensitivity for the detection of metastatic lesions in the post-operative patients with colorectal cancer when compared to conventional contrast-enhanced CT scans. The use of [99mTc]Tc-FAPI-46 SPECT/CT has the potential to significantly enhance the sensitivity of metastases detection, thereby influencing clinical decision-making in patients with colorectal cancer.
Keywords
[99mTc]Tc-FAPI
SPECT/CT
Contrast-enhanced CT
Colorectal cancer
Metastasis
Subjects
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