Document Type: Original Article
Research Institute for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran
Department of Radioisotope, Nuclear Research Center, AOEI, Tehran, Iran
Endocrine Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
Twenty-one patients with medullary thyroid carcinoma were studied prospectively with Tc-99m (V) DMSA after surgery. Pentavalent DMSA scintigram demonstrated abnormal uptake in 13 and equivocal uptake in 6 patients. Finally, seven patients with surgical or other imaging documentation were selected for this paper. Most of these patients were asymptomatic. Six patients had hypercalcitonemia and serum calcitonins was not measured in one patient. Whole body scan with Tc-99m (V) DMSA demonstrated abnormal radiotracer uptake in all patients locating in the neck (3 cases), mediastinum (5 cases), bone (2 cases), liver (1 case) and thyroid lobes (2 cases). This preliminary study with the locally developed Tc-99m (V) DMSA showed that it is a useful imaging agent for localization of metastatic lesions in asymptomatic patients with medullary thyroid carcinoma and high serum calcitonine.