1
Department of Radioisotope, Nuclear Research Center, AOEI, Tehran, Iran
2
Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract
Antibodies are a diverse class of glycoproteins that specially bind with antigen and elicit a number of secondary responses in vivo. Most of the applications of antibodies in basic research diagnosis and immunotherapy rely on labeling of the antibody with radiopharmaceuticals. Radiolabeled antibodies are a new class of imaging agents for the detection of sites of disease. True biodistribution of IgG has a great importance to develope antibody conjugates for delivering radionuclides or drugs to desired sites. In this study, IgG was iodinated by chloramine-T method. Injecting turpentine in the left thigh of mice induced inflammation. Distribution of I-125-IgG in normal and induced inflammation mice was assessed. Results showed the accumulation of I-125-IgG in inflammed muscle was more than normal muscle.
Babaei, M. H. , Najafi, R. and Shahhosseini, S. (1999). Distribution of I-125-IgG in normal and induced inflammation in mice [Persian]. Iranian Journal of Nuclear Medicine, 7(1), 42-47.
MLA
Babaei, M. H. , , Najafi, R. , and Shahhosseini, S. . "Distribution of I-125-IgG in normal and induced inflammation in mice [Persian]", Iranian Journal of Nuclear Medicine, 7, 1, 1999, 42-47.
HARVARD
Babaei, M. H., Najafi, R., Shahhosseini, S. (1999). 'Distribution of I-125-IgG in normal and induced inflammation in mice [Persian]', Iranian Journal of Nuclear Medicine, 7(1), pp. 42-47.
CHICAGO
M. H. Babaei , R. Najafi and S. Shahhosseini, "Distribution of I-125-IgG in normal and induced inflammation in mice [Persian]," Iranian Journal of Nuclear Medicine, 7 1 (1999): 42-47,
VANCOUVER
Babaei, M. H., Najafi, R., Shahhosseini, S. Distribution of I-125-IgG in normal and induced inflammation in mice [Persian]. Iranian Journal of Nuclear Medicine, 1999; 7(1): 42-47.
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