Preoperative assessment of meningioma aggressiveness by Thallium-201 brain SPECT

Document Type : Original Article

Authors

1 Department of Neurological Surgery, Dr Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

2 Department of Nuclear Medicine, Rajaei Cardiovasular, Medical & Research Center, Iran University of Medical Sciences, Tehran, Iran

3 Department of Pathology, Emam Hosein Hospital, Semnan University of Medical Sciences, Semnan, Iran

Abstract

Introduction: Meningioma is usually a benign brain tumor, but sometimes with aggressive course. The aim of this study was to assess the ability of 201Tl Brain SPECT to differentiate the pathologic grade of meningioma preoperatively.
Methods: Thirty lesions in 28 patients were evaluated in this study. Early (20 minutes) and late (3 hours) brain SPECT images were performed and early uptake ratio (EUR), late uptake ratio (LUR) and retention index (RI) were calculated. All patients were operated and pathologic grade of tumors were defined according to World Health Organization grading system.
Results: SPECT results were compared in different pathologic groups. Data analysis clarified no significant difference of EUR in benign and aggressive meningioma (P=0.2). However LUR and RI were significantly higher in aggressive tumors (P=0.001 and P=0.02, respectively).

Conclusion: According to our data Tl-201 Brain SPECT with early and late imaging has 80% sensitivity and specificity to differentiate malignant from benign meningioma.

Keywords

Main Subjects

References

van Alkemade H, de Leau M, Dieleman EM, Kardaun JW, van Os R, Vandertop WP, van Furth WR, Stalpers LJ. Impaired survival and long-term neurological problems in benign meningioma. Neuro Oncol. 2012 May;14(5):658-66.
Larjavaara S, Haapasalo H, Sankila R, Helén P, Auvinen A. Is the incidence of meningiomas underestimated? A regional survey. Br J Cancer. 2008 Jul 8;99(1):182-4.
Kinuya K, Ohashi M, Itoh S, Sakai S, Yamamoto K, Kakuda K, Nobata K, Terahata S, Taki S, Kinuya S. Thallium-201 brain SPECT to diagnose aggressiveness of meningiomas. Ann Nucl Med. 2003 Sep;17(6):463-7.
Marosi C, Hassler M, Roessler K, Reni M, Sant M, Mazza E, Vecht C. Meningioma. Crit Rev Oncol Hematol. 2008 Aug;67(2):153-71.
Valotassiou V, Leondi A, Angelidis G, Psimadas D, Georgoulias P. SPECT and PET imaging of meningiomas. ScientificWorldJournal. 2012;2012:412580.
Jaeckle KA. Neuroimaging for central nervous system tumors. Semin Oncol. 1991 Apr;18(2):150-7.
Monleón D, Morales JM, Gonzalez-Segura A, Gonzalez-Darder JM, Gil-Benso R, Cerdá-Nicolás M, López-Ginés C. Metabolic aggressiveness in benign meningiomas with chromosomal instabilities. Cancer Res. 2010 Nov 1;70(21):8426-34.
Hilbig A, Barbosa-Coutinho LM. Meningiomas and hormonal receptors. Immunohistochemical study in typical and non-typical tumors. Arq Neuropsiquiatr. 1998 Jun;56(2):193-9.
Quiñones-Hinojosa A1, Sanai N, Smith JS, McDermott MW. Techniques to assess the proliferative potential of brain tumors. J Neurooncol. 2005 Aug;74(1):19-30.
Tonami N. Thallium-201 SPECT in the evaluation of gliomas. J Nucl Med. 1993 Dec;34(12):2089-90.
Maddahi J, Berman D. Detection, Evaluation, and Risk Stratification of Coronary Artery Disease by Thallium-201 Myocardial Perfusion Scintigraphy. In: DePuey EG, Berman DS, Garcia EV. Cardiac SPECT imaging. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2001. p. 155-78.
Sun D, Liu Q, Liu W, Hu W. Clinical Application of 201Tl SPECT Imaging of Brain Tumors. J Nucl Med 2000; 41(1):5-10.
Nadel HR. Thallium-201 for oncological imaging in children. Semin Nucl Med. 1993 Jul;23(3):243-54.
Ancri D, Basset JY, Lonchampt MF, Etavard C. Diagnosis of cerebral lesions by Thallium 201.   Radiology. 1978 Aug;128(2):417-22.
Kaplan WD, Takvorian T, Morris JH, Rumbaugh CL, Connolly BT, Atkins HL. Thallium-201 brain tumor imaging: a comparative study with pathologic correlation. J Nucl Med. 1987 Jan;28(1):47-52.
Black KL, Hawkins RA, Kim KT, Becker DP, Lerner C, Marciano D. Use of thallium-201 SPECT to quantitate malignancy grade of gliomas. J Neurosurg. 1989 Sep;71(3):342-6.
Kim KT, Black KL, Marciano D, Mazziotta JC, Guze BH, Grafton S, Hawkins RA, Becker DP. Thallium-201 SPECT imaging of brain tumors: methods and results. J Nucl Med. 1990 Jun;31(6):965-9.
Kosuda S, Fujii H, Aoki S, Suzuki K, Tanaka Y, Nakamura O, Shidara N. Reassessment of quantitative thallium-201 brain SPECT for miscellaneous brain tumors. Ann Nucl Med. 1993 Nov;7(4):257-63.
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007 Aug;114(2):97-109.
Datta NR, Pasricha R, Gambhir S, Prasad SN, Phadke RV. Comparative evaluation of 201Tl SPECT and CT in the follow-up of irradiated brain tumors. Int J Clin Oncol. 2004 Feb;9(1):51-8.
Sugo N, Kuroki T, Nemoto M, Mito T, Seiki Y, Shibata I. Difference in 201TlCl accumulation mechanism in brain tumors: a comparison of their Na(+)-K+ ATPase activities. Kaku Igaku. 2000 Jul;37(4):311-8.
Taki S, Kakuda K, Kakuma K, Kobayashi K, Ohashi M, Ito S, Yokoyama M, Annen Y, Tonami N. 201Tl SPET in the differential diagnosis of brain tumours. Nucl Med Commun. 1999 Jul;20(7):637-45.
Ooigawa H, Miyazawa T, Otani N, Fukui S, Nawashiro H, Shima K. Usefulness of thallium-201 chloride single photon emission computed tomography for the preoperative diagnosis of fourth ventricle meningioma--case report. Neurol Med Chir (Tokyo). 2004 Dec;44(12):660-4.
Iranian Journal of Nuclear Medicine
Volume 23, Issue 2 - Serial Number 44
Serial number: 44
July 2015
Pages 82-88

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