Document Type: Original Article
Radiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Radiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
Introduction:Brain imaging with F-18 fluorodeoxyglucose (18F-FDG) positron emission tomography or Tc-99m hexamethylpropyleneamine oxime (99mTc-HMPAO) SPECT is widely used for the evaluation of Alzheimer's dementia (AD); we aim to assess superiority of one method over the other.
Methods: Twenty four patients with clinical diagnosis of Alzheimer disease underwent 18F-FDG PET and 99mTc-HMPAO SPECT in order to assess the zones of hypo metabolism & hypoperfusion specific for Alzheimer's disease.
Results: 18F-FDG PET showed specific zones of hypometabolism in 19 patients (79.1%) while SPECT was positive in 15 cases (62.5%) with statistically significant difference (P= 0.027).
Conclusion: 18F-FDG PET was significantly superior to HMPAO SPECT and 18F-FDG PET could replace the classic role of perfusion SPECT in diagnosis of Alzheimer's disease.