Document Type: Original Article
Department of Radioisotope, Nuclear Research Center, AOEI, Tehran, Iran
In recent years, several radiopharmaceuticals have been developed for imaging regional cerebral blood flow (rCBF) such as 75Se labelled PIPSE and MOSE, ²º¹TI labelled DDC and 99mTc labelled HMPAO. HMPAO with two asymmetric carbon atoms (At the 3 and 9 positions), produces d,1 and meso isomers, only one of which is retained in the brain. Rapid intracellular conversion of 99mTc-d,1-HMPAO to hydrophilic 99mTC species causes the complex becoming fixed in the brain. In this report we synthesized and characterized d,1-HMPAO. Kit formulations have been done and biological characteristics of 99mTc-d,1-HMPAO have been examined.