Comparison of Tc-99m Ethylenedicysteine (Tc-99m EC) with Tc-99m DPTA in evaluation of renal disease [Persian]

Document Type : Original Article


Research Institute for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran


Tc-99m-EC is a new renal radiopharmaceutical introduced as an alternative for Tc-99m MAG3. Twenty-three normal volunteers and patients in different .stages of renal disease were evaluated with Te-99m EC and Tc-99m DTPA. The mean initial uptake of EC was significantly higher as compared to DTPA. There was a high correlation between rectangular and hand-drawn ROls for kidney and background, 0.96 and 0.94 for right and left kidney, respectively. There was no significant difference between supra and subrenal background activities. A high correlation was also noticed between renal uptake of both agents divided by their injected original dose, and with correlation coefficient of 0.88 and 0.85 for the right and left kidneys, respectively. The relative right kidney uptake of two agents was nearly similar (with correlation coefficient of 0.92). The quality of the renogram generated with EC was belter than those obtained with DTPA. The results show that Tc-99m EC has good characteristics to be used as an agent for evaluation of renal function and morphology.

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