Incidental finding of 68Ga-PSMA uptake in covid-19 induced pneumonia

Document Type : Case Report


1 Kidney Transplantation and Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

2 Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

3 Nuclear Medicine Department, Razavi Hospital, Imam Reza International University, Mashhad, Iran


A 68 years old man with prostate carcinoma was referred for 68Ga-PSMA PET/CT scan because of recent significant rise of PSA. He complained of muscle weakness and fatigue, since 3 weeks before the scan, without dyspnea or shortness of breath. In his 68Ga-PSMA-617 PET/CT study, widespread skeletal metastasis, as well as liver involvement were noticed. Also, multiple bilateral patchy areas of ground glass opacities were noticed in peripheral areas of both lung fields, which showed typical pattern of covid-19 pneumonia. These lung lesions showed relatively significant PSMA uptake which were about twice of the liver uptake. Serology test which was performed later, confirmed covid-19 infection.


Main Subjects

  1. Ceci F, Fanti S. PSMA-PET/CT imaging in prostate cancer: why and when. Clin Transl Imaging. 2019;7:377-79.
  2. Dhawan RT, Barwick TD, Khan S, Lewington VJ, Dharmarajah N. PSMA PET ligands in prostate cancer: a gameā€changer? Trends Urol. Men's Health. 2019;10(4):7-13.
  3. Demirci  E, Ocak M, Kabasakal L, Decristoforo C, Talat Z, Halaç M, Kanmaz B. (68)Ga-PSMA PET/CT imaging of metastatic clear cell renal cell carcinoma. Eur J Nucl Med Mol Imaging. 2014 Jul;41(7):1461-2.
  4. Shetty D, Patel D, Le K, Bui C, Mansberg R. Pitfalls in gallium-68 PSMA PET/CT interpretation—a pictorial review. Tomography. 2018 Dec;4(4):182-193.
  5. Hamid S, Mir MY, Rohela GK. Noval coronavirus disease (COVID-19): A pandemic (Epidemiology, Pathogenesis and potential therapeutics). New Microbes New Infect. 2020 Apr 14;35:100679.