A rare case of primary malignant melanoma of cervix with metastasis to inguinal lymph node detected on 18F-FDG PET-CT scan

Document Type: Case Report

Authors

1 Department of Nuclear Medicine, Eastern Command Hospital, Kolkata, India

2 Department of Nuclear Medicine, Southern Command Hospital, Pune, India

Abstract

Primary malignant melanoma of uterine cervix is extremely rare malignancy with very few case published reports. This neoplasm is having poor prognosis, so early diagnosis, staging and treatment is of extreme importance. 18F-FDG PET-CT (18F-labeled fluoro-2-deoxyglucose positron emission computed tomography) scan is an established modality to determine exact extent of disease in malignant melanoma thus determining the treatment protocol. In this reported case, PET-CT is showing primary lesion in uterine cervix with extension in to the vagina and involvement of left inguinal lymph nodes. No other abnormal 18F-FDG avid lesion or distant metastases noted in the scanned region of the body.

Keywords

Main Subjects


  1. Patrick RJ, Fenske NA, Messina JL. Primary mucosal melanoma. J Am Acad Dermatol. 2007 May;56(5):828-34.
  2. Yücesoy G, Kus E, Cakiroglu Y, Muezzinoglu B, Yildiz K, Yucesoy I. Primary malignant melanoma of the cervix: report of a case. Arch Gynecol Obstet. 2009 Apr;279(4):573-5.
  3. Pusceddu S, Bajetta E, Carcangiu ML, Formisano B, Ducceschi M, Buzzoni R. A literature overview of primary cervical malignant melanoma: an exceedingly rare cancer. Crit Rev Oncol Hematol. 2012 Feb;81(2):185-95.
  4. McLaughlin CC, Wu XC, Jemal A, Martin HJ, Roche LM, Chen VW. Incidence of noncutaneous melanomas in the U.S. Cancer. 2005 Mar 1;103(5):1000-7.
  5. Benson RJ, Tan LT. Radiation-induced malignant melanoma of the cervix Clin Oncol (R Coll Radiol). 2000;12(4):234-7.
  6. Pusceddu S, Bajetta E, Carcangiu ML, Formisano B, Ducceschi M,. Buzzoni R, A literature overview of primary cervical malignant melanoma: an exceedingly rare cancer. Crit Rev Oncol Hematol. 2012  Feb;81(2):185-95.
  7. Clark KC, Butz WR, Hapke MR. Primary malignant melanoma of the uterine cervix: case report with world literature review. Int J Gynecol Pathol. 1999 Jul;18(3):265-73.
  8. Mordel N, Mor-Yosef S, Ben-Baruch N, Anteby SO. Malignant melanoma of the uterine cervix: case report and review of the literature. Gynecol Oncol. 1989 Mar;32(3):375-80.
  9. Hinde EF, Amal B, Hannane S, Cherhazade B, Abdelaziz B, Nawfel M, Omar M. Unusual primary location of the malignant melanoma, the cervico-vaginal region: 3 cases and literature review. Open J Obstet Gynecol. 2012;2(3):279-282.
  10. Deshpande AH, Munshi MM. Primary malignant melanoma of the uterine cervix: report of a case diagnosed by cervical scrape cytology and review of the literature. Diagn Cytopathol. 2001 Aug;25(2):108-11.
  11. Oudoux A, Rousseau T, Bridji B, RescheI, Rousseau C. Interest of F-18 fluorodeoxyglucose positron emission tomography in the evaluation of vaginal malignant melanoma. Gynecol Oncol. 2004 Dec;95(3):765-8
  12. Reinhardt MJ, Joe AY, Jaeger U, Huber A, Matthies A, Bucerius J, Roedel R, Strunk H, Bieber T, Biersack H, Tüting T. Diagnostic performance of whole body dual modality 18F-FDG PET/CT imaging for N- and M-staging of malignant melanoma: experience with 250 consecutive patients. J Clin Oncol. 2006 Mar 1;24(7):1178-87.