Ectopic intrathyroidal parathyroid adenoma mimicking thyroid nodule: A diagnostic challenge solved by [99mTc]Tc-MIBI SPECT/CT

Articles in Press

Document Type : Case Report

Authors

Department of Nuclear Medicine and Theranostic Moleculer, School of Medicine, Universitas Padjajaran, Hasan Sadikin General Hospital, Bandung, Indonesia

10.22034/irjnm.2025.130060.1684

Abstract

Primary hyperparathyroidism (PHPT) is an endocrine disorder characterized by excessive secretion of parathyroid hormone (PTH), commonly due to a parathyroid adenoma. We present a rare case of a 21-year-old female diagnosed with PHPT caused by a parathyroid adenoma Type G, an intrathyroidal variant. The patient exhibited severe skeletal manifestations, including multiple thoracic vertebral fractures, significant height reduction, and hypercalcemia (serum calcium: 11.4 mg/dL). [99mTc]Tc-MIBI SPECT/CT imaging localized the adenoma in the middle pole of the right thyroid lobe. The patient underwent successful right isthmolobectomy and parathyroidectomy, leading to normalization of PTH and calcium levels. This case highlights the importance of nuclear medicine imaging in accurately diagnosing and guiding surgical intervention for rare parathyroid adenoma subtypes.

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References

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Iranian Journal of Nuclear Medicine

Articles in Press, Accepted Manuscript
Available Online from 28 December 2026

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