[99mTc]Tc-MDP scintigraphy in osteopoikilosis

Articles in Press

Document Type : Case Report

Author

Oncology and Hematology Research Center, Alkafeel Hospital, Alameed Medical University, Karbala, Iraq

10.22034/irjnm.2025.130137.1696

Abstract

Osteopoikilosis (OPK) is a rare, benign sclerosing bone dysplasia often discovered incidentally during radiographic evaluations.  We report the case of a 37-year-old male with bilateral hip pain and radiographic evidence of multiple sclerotic lesions, initially raising concern for osteoblastic metastasis. Laboratory findings were unremarkable. [99mTc]Tc-Methylene diphosphonate (MDP) scan performed three hours after administration of 20 mCi (740 MBq) of radiotracer showed no increased uptake at lesion sites, ruling out metastasis and supporting the OPK diagnosis. Further evaluation revealed similar radiographic findings in the patient's asymptomatic brother, confirming familial OPK. This case highlights the diagnostic importance of nuclear imaging in distinguishing OPK from metastatic disease and emphasizes the need for awareness to avoid unnecessary interventions.

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References

  1. Al-Khudairi R, Maris A, Blehadj A, Vasiliadis AV. Osteopoikilosis in a patient with familial adenopolyposis : a case report. Radiol Case Rep. 2024 Aug 2;19(10):4485-8.
  2. Tuncel M, Caner B. Osteopoikilosis: a major diagnostic problem solved by bone scintigraphy. Rev Esp Med Nucl Imagen Mol. 2012 Mar-Apr;31(2):93-6.
  3. Liu B, Ma L, Zhang B, Wu G. Distal radius fracture combined with osteopoikilosis in a young adult patient: a first case report. Asian J Surg. 2024 Sep 12:S1015-9584(24)02079-7.
  4. Hellemans J, Preobrazhenska O, Willaert A, Debeer P, Verdonk PC, Costa T, Janssens K, Menten B, Van Roy N, Vermeulen SJ, Savarirayan R, Van Hul W, Vanhoenacker F, Huylebroeck D, De Paepe A, Naeyaert JM, Vandesompele J, Speleman F, Verschueren K, Coucke PJ, Mortier GR. Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis. Nat Genet. 2004 Nov;36(11):1213-8.
  5. Tsai SY, Wang SY, Shiau YC, Wu YW. Benign incidental findings of osteopoikilosis on Tc-99m MDP bone SPECT/CT: A case report and literature review. Medicine (Baltimore). 2016 Jun;95(23):e3868.
  6. Carpintero P, Abad JA, Serrano P, Serrano JA, Rodríguez P, Castro L. Clinical features of ten cases of osteopoikilosis. Clin Rheumatol. 2004 Dec;23(6):505-8.
  7. Mohsenpour B, Ahmadi A. Osteopoikilosis: a case report. J Med Case Rep. 2023 Jul 12;17(1):292.
  8. Appenzeller S, Castro GR, Coimbra IB. Osteopoikilosis with abnormal bone scan: long-term follow-up. J Clin Rheumatol. 2007 Oct;13(5):291-2.
  9. Shahid L, Siddique U, Khan Z. Osteopikilosis Punctata–benign spotted disease; a case report a rare cause of bone pain and mimicker of metastasis on radiographs. Pak J Radiol. 2024;34(4):250-3
  10. Wordsworth P, Chan M. Melorheostosis and osteopoikilosis: a review of clinical features and pathogenesis. Calcif Tissue Int. 2019 May;104(5):530-43.
Iranian Journal of Nuclear Medicine

Articles in Press, Accepted Manuscript
Available Online from 27 December 2026

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