A new approach to scatter correction in SPECT images based on Klein_Nishina equation

Document Type : Original Article

Authors

1 Medical Physics Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Medical Physics Department, Mashhad University of Medical Science, Mashhad, Iran

3 Department of Nuclear Medicine, Wilhelminenspital, Vienna, Austria

4 Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Abstract

Introduction: Scattered photon is one of the main defects that degrade the quality and quantitative accuracy of nuclear medicine images. Accurate estimation of scatter in projection data of SPECT is computationally extremely demanding for activity distribution in uniform and non-uniform dense media.
Methods: The objective of this paper is to develop and validate a scatter correction technique that use an accurate analytical model based on Klein_Nishina scatter equation and compare Klein_Nishina scatter estimation with triple energy window. In order to verify the proposed scattering model several cylindrical phantoms were simulated. The linear source in the cylindrical Phantoms was a hot rod filled with 99mTc. K factor defines as the ratio of scatter resulting from MC simulation to scatter estimated from Klein_Nishina formula. Also a SPECT/CT scan of the image quality phantom was acquired. Row data were transferred to a PC computer for scatter estimation & processing of the images using MLEM iterative algorithm in MATLAB software.
Results: The scatter and attenuation compensated images by the proposed model had better contrast than uncorrected and only attenuation corrected images. The K-factors that used in proposed model doesn’t vary with different activities & diameters of linear source and they’re just a function of depth and composition of pixels.

Conclusion: Based on Mont Carlo simulation data, the K_N formula that used in this study demonstrates better estimation of scattered photons than TEW. Proposed scattered correction algorithm will improve 52.3% in the contrast of the attenuated corrected images of image quality phantom.

Keywords

Main Subjects


Blundell HL, Middleton GW, Lee AJ, Tweddel AC. The impact of scatter correction of SPECT myocardial perfusion images on the clinical report. Nucl Med commun. 2001;22(4):434.
Kangasmaa TS, Kuikka JT, Vanninen EJ, Mussalo HM, Laitinen TP, Sohlberg AO. Half-time myocardial perfusion SPECT imaging with attenuation and Monte Carlo-based scatter correction. Nucl Med Commun. 2011 Nov;32(11):1040-5.
Ali L, Khalil M, Muddei S, Burezq S, Al-Hajri B. Ga-67 scintigraphic imaging: role of combined optimized energy photopeaks and scatter correction in improving lesion detectability. Nucl Med Commun. 2011 Aug;32(8):724-30.
Hutton BF, Buvat I, Beekman FJ. Review and current status of SPECT scatter correction. Phys Med Biol. 2011 Jul 21;56(14):R85-112.
King MA, Hademenos GJ, Glick SJ. A dual-photopeak window method for scatter correction. J Nucl Med. 1992 Apr;33(4):605-12.
Floyd CE Jr, Jaszczak RJ, Greer KL, Coleman RE. Deconvolution of Compton scatter in SPECT. J Nucl Med. 1985 Apr;26(4):403-8.
Meikle SR, Hutton BF, Bailey DL. A transmission-dependent method for scatter correction in SPECT. J Nucl Med. 1994 Feb;35(2):360-7.
Narita Y, Eberl S, Iida H, Hutton BF, Braun M, Nakamura T, Bautovich G. Monte Carlo and experimental evaluation of accuracy and noise properties of two scatter correction methods for SPECT. Phys Med Biol. 1996 Nov;41(11):2481-96.
Ogawa K, Harata Y, Ichihara T, Kubo A, Hashimoto S. A practical method for position-dependent Compton-scatter correction in single photon emission CT. IEEE Trans Med Imaging. 1991;10(3):408-12.
Koral KF, Wang XQ, Rogers WL, Clinthorne NH, Wang XH. SPECT Compton-scattering correction by analysis of energy spectra. J Nucl Med. 1988 Feb;29(2):195-202.
Pretorius PH, van Rensburg AJ, van Aswegen A, Lötter MG, Serfontein DE, Herbst CP. The channel ratio method of scatter correction for radionuclide image quantitation. J Nucl Med. 1993 Feb;34(2):330-5.
de Vries DJ, King MA, Soares EJ, Tsui BMW, Metz, CE. Evaluation of the effect of scatter correction on lesion detection in hepatic SPECT imaging. IEEE Trans Nucl Sci. 1997;44(5):1733-40.
Larsson A, Johansson L, Sundström T, Ahlström KR. A method for attenuation and scatter correction of brain SPECT based on computed tomography images. Nucl Med Commun. 2003 Apr;24(4):411-20.
Lagerburg V, de Nijs R, Holm S, Svarer C. A comparison of different energy window subtraction methods to correct for scatter and downscatter in I-123 SPECT imaging. Nucl Med Commun. 2012 Jul;33(7):708-18.
Frey EC, Tsui BMW. A practical method for incorporating scatter in a projector-backprojector for accurate scatter compensation in SPECT. IEEE Trans Nucl Sci. 1993;40(4):1107-16.
Frey EC, Ju ZW, Tsui BMW. A fast projector-backprojector pair modeling the asymmetric, spatially varying scatter response function for scatter compensation in SPECT imaging. IEEE Trans Nucl Sci. 1993;40(4):1192-97.
Beekman FJ, Eijkman EGJ, Viergever MA, Borm GF, Slijpen ETP. Object shape dependent PSF model for SPECT imaging. IEEE Trans Nucl Sci. 1993;40(1):31-39.
Frey EC, Tsui BMW. A new method for modeling the spatially-variant, object-dependent scatter response function in SPECT. IEEE Nucl Sci Symp Med Imaging Conf. 1996;2:1082-86.
Klein–Nishina formula. [http://en.wikipedia.org/wiki/Klein%E2%80%93Nishina_formula].
Harrison R. SimSET. [http://depts.washington.edu/simset/html/simset_main.html].
PET Emission Phantom acc NEMA NU2-2007.  [http://www.ptw.de/pet_emission_phantom_nema.html].
Knoll P, Kotalova D, Köchle G, Kuzelka I, Minear G, Mirzaei S, Sámal M, Zadrazil L, Bergmann H. Comparison of advanced iterative reconstruction methods for SPECT/CT. Z Med Phys. 2012 Feb;22(1):58-69.
Riauka TA, Gortel ZW. Photon propagation and detection in single-photon emission computed tomography--an analytical approach. Med Phys. 1994 Aug;21(8):1311-21.
Riauka TA, Hooper HR, Gortel ZW. Experimental and numerical investigation of the 3D SPECT photon detection kernel for non-uniform attenuating media. Phys Med Biol. 1996 Jul;41(7):1167-89.
Wells RG, Celler A, Harrop R. Analytical calculation of photon distributions in SPECT projections. IEEE Trans Nucl Sci. 1998;45(6):3202-14.
de Waard JC. Image reconstruction methods for emission based tomography. Master thesis. Faculty of Science, Utrecht University; 2011.
Seo Y, Wong KH, Sun M, Franc BL, Hawkins RA, Hasegawa BH. Correction of photon attenuation and collimator response for a body-contouring SPECT/CT imaging system. J Nucl Med. 2005 May;46(5):868-77.
Teimourian B, Ay MR, Zafarghandi MS, Ghafarian P, Ghadiri H, Zaidi H. A novel energy mapping approach for CT-based attenuation correction in PET. Med Phys. 2012 Apr;39(4):2078-89.
Kheruka S, Naithani U, Maurya A, Painuly N, Aggarwal L, Gambhir S. A study to improve the image quality in low-dose computed tomography (SPECT) using filtration. Indian J Nucl Med. 2011 Jan;26(1):14-21.
Kalantari F, Rajabi H, Saghari M. Quantification and reduction of attenuation related artifacts in SPET by applying attenuation model during iterative image reconstruction: a Monte Carlo study. Hell J Nucl Med. 2011 Sep-Dec;14(3):278-83.